Marine Bioresources - 8 > 12 octobre 2018
      • Le 09/09/2018
      • SPEAKERS OF THE SESSION: "BT2a - Healthcare: innovation and inspiration from the seas"

      • Wednesday 10 Octobre, afternoon | Meridienne room
        Session in English
      • sessions siteweb 286x231 v4.jpg
      • Organised by: ID2Santé

        Keywords: Health, Nutrition, Therapeutic molecules, Medical devices


        This session will show how companies innovate in human health being inspired by the marine life to design medical devices, therapeutic molecules and innovative food complements.




        Welcome speech by Jocelyne LE SEYEC, ID2Santé, France.


        15h05 – 15h20:

        Short introduction by David J. NEWMAN, retired Chief of Natural Product Branch at the National Cancer Institute (NCI), USA.


        15h20 – 15h40:

        Alexis MEHAIGNERIE, Abyss Ingredients, France.

        Brain Booster project: marine bioactive molecules for healthy ageing.

        Due to improved nutrition and care, life span is continuously increasing in humans and pets. Advanced age is frequently associated with an increased number of age-related physiological changes, possibly affecting health and welfare. But aging is a complex biological process, partly due to oxidative stress and inflammation. Therefore, nutritional and nutraceutical solutions addressing these imbalances may represent promising strategies for aged subjects. The valorization of sardine by-products, in particular, seems very attractive to prevent and counteract age-related effects. The aim of Brain Booster’s project is to develop an innovative ingredient combining marine bioactive molecules, with demonstrated efficacy on the prevention of age-related cognitive decline.


        15h40 – 16h00:

        Jean-Paul CADORET, Greensea, France.

        Red and blue algae pigments: food and health domains applications.

        Algae contain a wide range of pigments including fluorescent protein such as phycobiliproteins, which participate in an extremely efficient way to energy transfer chain in photosynthesis, responsible for about 50% of light capture for cyanobacteria and red algae for example. The three main groups of phycobiliprotein are phycocyanins, allophycocyanins and phycoerythrins. Recent studies have demonstrated the hepatoprotective, anti-inflammatory and antioxidant properties of these pigments as well as antiproliferative activities. They enhance biological defense activity against infectious diseases sustaining functions of the immune system and reduce allergic inflammation. Phycocyanin is also used in food industry as a natural blue-dye and the actual demand for natural pigments is tremendous. With a world demand of over 100 metric tons, the global market is expected to continue to grow. Greensea participates to this trend with applications calling for the use of fluorescent pigments in the early detection of dental caries or in providing pure red and blue pigments aimed at the preparation of commercial medical diagnostic kits for numerous diseases.


        16h00 – 16h15:

        Charlotte CORPOREAU and Daniela ZEPPILLI, Ifremer, France.

        Focus on "Sea and Health: marine species, reservoirs of molecules for human health" conference.

        A summary and conclusions from the conference that took place in the 8th and 9th of October around the following themes: new molecules and new mechanisms, marine fungi, marine micro and macro algae and marine bacteria.


        16h15 – 16h35: Jaran RAUO, Marealis AS, Norway

        Peptides extracted from the shell of Pandalus borealis: potent blood pressure lowering effect


        Marealis AS is a Norwegian company owned by Stella Polaris AS. Stella Polaris AS is probably the world’s largest producer of cooked and peeled coldwater prawns (P. borealis) and generates several thousand tons of shrimp shell per year.

        Marealis AS was established in 2008 to bring forward a scientific finding from the Norwegian Institute of Fishery Technology Research (now named Nofima) which said that peptides extracted from the shell of Pandalus borealis had a potent blood pressure lowering effect in-vitro.
        Through cooperation with Nofima, the University of Tromso and other scientific institutions and CROs in Norway and abroad, Marealis has developed a Refined Shrimp Peptide Concentrate (RSPC) which is clinically documented for having significant blood pressure lowering effect. The product is approved in by Health Canada, FDA/USA, and EFSA/EU and commercialized now in Canada followed by the US market and Europe.
        As Marealis will continue doing sales and marketing, we have from the knowledge and network acquired through developing Marealis RSPC, established a new company, Marealis Innovation AS, to bring more high-quality and high-value products to market. All from by-products from the seafood industry.


        16h35: Coffee break


        17h00 – 17h20:

        Franck ZAL, Hemarina, France.

        HEMO2life®: promising strong ally in organ transplant.

        Hemarina SA is a privately held biotechnology company centered on the development of marine oxygen carriers from Arenicola marina lugworm. The company has developed a technological platform opening the door to a dozen of therapeutic and industrial applications. The first medical device developed by Hemarina is HEMO2life®, an additive to all organ preservation methods currently used worldwide in hospitals. HEMO2life® provides time and organs in better conditions to surgeons, since organs could survive only a few hours after harvesting on the donors. HEMO2life® showed its safety and efficiency during a multi-centered clinical trial performed on kidney transplantation and more recently on the second face graft realized by the team of Pr. Lantieri in Georges Pompidou European Hospital. HEMO2life® is currently on the way to be approved by the European authorities.


        17h20 – 17h40:

        Mélody DUTOT, Yslab, France.

        Stimulation of the airway innate immune response by marine solution containing fucoidans.

        Natural treatments can help to maintain homeostasis of the immune system and enhance resistance to microbial attacks. Polysaccharides from brown algae, mainly fucoidans, exhibit various immunomodulatory effects. Our objective is to evaluate the effects of a marine solution containing fucoidans on bacterial- and viral-induced responses in human macrophages and bronchial epithelial cells. We concluded that the fucoidan marine solution stimulated defense mechanisms like autophagy and inhibited proinflammatory cytokine production by macrophages and bronchial epithelial cells. The fucoidan marine solution locally applied might contribute to the treatment of upper airway inflammation caused by viral or bacterial infections.


        17h40 – 18h00:

        Laurent MEIJER, Manros Therapeutics, France.

        "From Sea to Pharmacy", a dream illustrated by a few concrete examples in cystic fibrosis, Down syndrome and Alzheimer's disease.

        Marine organisms represent a very rich source of enzymes and natural products which can be exploited to understand human disease and develop new therapeutic drugs. This "From Sea to Pharmacy" dream will be illustrated by a few examples from our own laboratory. Total purification, from starfish oocytes, of CDK1/cyclin B, the prophase/metaphase regulating protein kinase, allowed the discovery of roscovitine, a drug candidate in phase 2 clinical trial for the treatment of chronically infected cystic fibrosis patients. Medicinal chemistry starting from Leucettamine B, a natural product extracted from the marine calcareous sponge Leucetta has led to the discovery of Leucettines, a class of kinase inhibitors developed for the treatment of cognitive deficits in Down syndrome and Alzheimer's disease.



        Conclusion by David J. NEWMAN, retired Chief of Natural Product Branch at the NCI, USA.

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Organised by
  • Brest Métropôle
  • Technopôle Brest Iroise
With the support of
  • Union Européenne
  • Région Bretagne
  • Caisse des dépôts

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